李岩，华中科技大学同济医学院三级教授、博士生导师，国家高层次青年人才计划入选者，湖北省杰出青年基金获得者、湖北省公共卫生青年拔尖人才。现任人畜共患传染病重症诊治全国重点实验室（华中科技大学）业务副主任、病原生物学系党支部书记、华中科技大学生物冷冻电镜平台用户委员会主任。兼任中华医学会微生物学与免疫学分会委员、中华医学会医学病毒学分会青年委员、湖北省医学会微生物与免疫学分会候任主任委员、湖北省生物物理学会常务理事、湖北省医学会热带病与寄生虫学分会委员等多个学术职务，并担任VIEW Medicine副主编、Journal of Cellular Biochemistry编委、Military Medical Research青年编委及The BMJ等二十余个期刊审稿人。

本科毕业于中国科学技术大学，博士毕业于新加坡南洋理工大学，曾在新加坡国家药物研发机构从事多年创新药物研发工作。长期聚焦耐药细菌、呼吸道病毒、利什曼原虫等人畜共患病原体的致病分子机制与精准干预策略，综合运用生物化学、结构生物学、分子生物学、人工智能等多学科手段，探索病原-宿主互作机制与靶向干预路径，致力于从基础机制研究走向技术转化和产业应用。

以（共同）通讯或第一作者在Science、Lancet Microbe、Nature Communications、Nucleic Acids Research、Journal of Virology、Journal of Infection等期刊发表SCI论文40余篇，H因子28，并参编高等教育出版社出版的《医学微生物学》等教材。在人才培养方面，注重科研训练与实践能力并重，持续指导学生参与高水平学科竞赛，团队在国家级、省级及校级赛事中多次获奖，并入选学校示范性学生创新团队，育人成效显著，具有良好的示范引领作用。

主持国家自然科学基金专项项目与面上项目、湖北省杰出青年基金、武汉市卫健委项目及多项企业合作课题，作为骨干成员参与多个国家重点研发计划和省级创新研究群体项目。已申请药物发明专利5项，多个新药研发项目已进入临床试验阶段，相关产品销往十余个国家。曾荣获中国青年“创青春”大赛金奖、华为最佳创新合作奖、湖北省科学技术进步奖、华中科技大学青年五四奖章、基础医学院科技创新优秀指导教师等荣誉，入选湖北省科协优秀科技论文（2023年度），相关成果被央视等主流媒体专题报道。

代表性文章：

#Co-first author *Corresponding author

1. Kang, Y.#, Liu, Y.#, Zhou, H.#, Ma,B., Chen, H., Zhang, K., Wang, Y., Fan, C., Yang, H., Xu, Y., Matthews, S., Yuan, S.*,Li, Y.*, & Liu,B.*(2025).A Temperature-driven DNA discrimination strategy to distinguishE. coliDNA and phage 5hmC-modified DNA.Nucleic Acids Research, 53(11), gkaf501.

2. Yu, M.#, Wang, J.#, Zhang, X., Zhang, H., Li, C., Li, J., Lin, J., Zheng, J., Huang, L.,Li, Y.*,&Sun, S.*(2025).The mechanism of YAP/TAZ transactivation and dual targeting for cancer therapy.Nature Communications, 16, 3855.

3. Zhang, H.#, Yan, R.#, Liu, Y.#, Yu, M.#, He, Z., Xiao, J., Li, K., Liu, G., Ning, Q.*, &Li, Y.*(2025).Progress in antileishmanial drugs: Mechanisms, challenges and prospects.PLOS Neglected Tropical Diseases, 19(1), e0012735.

4. Ke,Z.#,Zhang, H.#, Wang, Y., Wang, J., Peng, F., Wang, J., Liu, X.*, Hu, H.*,&Li, Y.*(2024).N-terminus of SARS-CoV-2 nonstructural protein 3 interrupts RNA-driven phase separation of N protein by displacing RNA.Journal of Biological Chemistry,300(11), 107828.

5. Peng, F., Ke, Z., Jin, H., Wang, W.,Zhang, H.*,&Li, Y.*(2024).Structural insights into the regulation mechanism ofMycobacterium tuberculosisMftR.The FASEB Journal, 38, e23724.

6. Zhang, H.#, Zhou, K.#, Peng, F.#, Gao, Z.#, Song, G.#*, Hu, B., Chun, S., Xiao, J., Qian, M., Wu, J., Pan, K., Gao, F., Guo, M., Peng, C., Zou, G., Wu, J., Cai, K.*,&Li, Y.*(2024).Novel small-molecule inhibitors of SARS-CoV-2 main protease with nanomolar antiviral potency.Journal ofInfection, 88(2), 211-214.

7. Zhang, H.#, Lv, P.#, Jiang, J., Liu, Y., Yan, R., Shu, S., Hu, B.,Xiao, H.,Cai, K.,Yuan,S.*,&Li, Y.* (2023).Advances in developing of ACE2 derivatives against SARS-CoV-2.The Lancet Microbe,4(5), e369-e378.

8. Lv, P.#, Hu, B.#, Hua, R.#, Zhang, J.#,Zhang, H., Liu, Z., Xu, L., He, Z., Li, X., Guo, M., Pan, K., Zhang, Z., Zeng, Q., Wu, Z., Sun, L., Guo, M., Zhou, L., Xu, X., Yu, B., Xu, J., Yuan, S., Guo, M.*, Cai, K.*, Xia, Y.*,&Li, Y.* (2022).A novelly designed protein antagonist confers potent neutralization against SARS-CoV-2 variants of concern.Journal of Infection,85(3), e72-e76.

9. Zhao, K.#, Ke, Z.#, Hu, H.#, Liu, Y., Li, A., Hua, R., Guo, F., Xiao, J., Zhang, Y., Duan, L, Yan, X., Gao, Y., Liu, B., Xia, Y.*,&Li, Y.* (2021). Structural basis and function of the N-terminus of SARS-CoV-2 nonstructural protein 1.Microbiology Spectrum, 9(1), e00169-21.

10. Xu, C.#, Ke, Z.#, Liu, C.#, Wang, Z.#, Liu, D., Zhang, L., Wang, J., He, W., Xu, Z., Li, Y., Yang, Y., Huang, Z., Lv, P., Wang, X., Han, D.*,Li, Y.*, Qiao, N.*,&Liu, B.* (2020). Systemicin silicoscreening in drug discovery for coronavirus disease (COVID-19) with an online interactive web server.Journal of Chemical Information and Modeling,60(12), 5735-5745.

11. Lau, Q.#, Li, J.#,Sani, M.#, Sinha, S.#,Li, Y.#, Ng, F., Kang, C., Bhattacharjya, S., Separovic, F., Verma, C., & Chia, C.* (2018). Elucidating the bactericidal mechanism of action of the linear antimicrobial tetrapeptide BRBR-NH2.Biochimica et Biophysica Acta (BBA) - Biomembranes,1860(8), 1517-1527.

12. Li, Y.#, Zhang, Z.#, Phoo, W.#, Loh, Y., Li, R., Yang, H., Jansson, A., Hill, J., Keller, T., Nacro, K.*, Luo, D.*, & Kang, C.* (2018). Structural insight into the inhibition of Zika virus NS2B-NS3 protease by a small-molecule inhibitor.Structure, 26(4), 555-564.e3.

13. Li, Y.#, Zhang, Z.#, Phoo, W., Loh, Y., Wang, W., Liu, S., Chen, M., Hung, A., Keller, T., Luo, D.*, & Kang, C.* (2017). Structural dynamics of Zika virus NS2B-NS3 protease binding to dipeptide inhibitors.Structure, 25(8), 1242-1250.e3.

14. Zhang, Z.#,Li, Y.#, Loh, Y., Phoo, W., Hung, A., Kang, C.*, & Luo, D.* (2016). Crystal structures of unlinked NS2B-NS3 protease from Zika Virus.Science, 354(6319), 1597-1600.

15. Phoo, W.#,Li, Y.#, Zhang, Z., Lee, M., Loh, Y., Tan, Y., Ng, E., Lescar, J., Kang, C.*, & Luo, D.* (2016).Structureof the NS2B-NS3 protease from Zika virus after self-cleavage.Nature Communications, 7, 13410.

16. Li, Y.,Wong, Y., Lee, M., Li, Q., Wang, Q., Lescar, J., Shi, P., & Kang, C.* (2016). Secondary structure and membrane topology of the full-length Dengue Virus NS4B in micelles.Angewandte Chemie International Edition, 55(39), 12068-12072.

17. Li, Y., Wong, Y., Ng, F., Liu, B., Wong, Y., Poh, Z., Liu, S., Then, S., Lee, M., Ng, H., Huang, Q., Hung, A., Cherian, J., Hill, J., Keller, T., & Kang, C.* (2016).Escherichia colitopoisomerase IV E subunit and an inhibitor binding mode revealed by NMR spectroscopy.Journal of Biological Chemistry, 291(34), 17743-17753.

18. Li, Y.#, Li, Q.#, Wong, Y., Liew, L., & Kang, C.* (2015). Membrane topology of NS2B of dengue virus revealed by NMR spectroscopy.Biochimica et Biophysica Acta (BBA) - Biomembranes, 1848(10 Pt A), 2244-2252.

19. Li,Y.#, To,J.#,Verdia-Baguena,C.#, Dossena,S.,Surya, W., Huang, M.,Paulmichl,M.,Liu, D.,Aguilella, V.,&Torres,J.*(2014).Inhibition of thehumanrespiratorysyncytialvirussmallhydrophobicprotein andstructuralvariations in abicelleenvironment.Journal of Virology, 88(20), 11899-11914.

20. Li, Y.#, Surya, W.#, Claudine, S., & Torres, J.* (2014).Structure of a conserved Golgi complex-targeting signal in coronavirus envelope proteins.Journal of Biological Chemistry,289(18),12535-12549.

21. Wong, L.#,Li, Y.#, Pillay, S., Frolova, L., & Pervushin, K.* (2012). Selectivity of stop codon recognition in translation termination is modulated by multiple conformations of GTS loop in eRF1.Nucleic Acids Research, 40(12), 5751-5765.

热忱欢迎对传染病基础研究和药物转化研究有强烈兴趣的有志青年加入课题组。